Metabolic Programming In Obese people
Aug 31, 2009
The studies are being conducted worldwide to find out how early in life metabolic programming that affects the tendency of individuals to gain weight and become obese takes place in their brain. In a recent study at University of Buffalo the researchers found out that this metabolic programming that indicated to the onset of obesity during adulthood occurred in the fetuses of obese mother rats while they were still in the uterus. The study also pointed out to the fact that this programming happens in that part of brain which is in charge of maintaining the body weight of the living being throughout its life. This part of the brain of the fetes is called fetal hypothalamus.
Mulchand Patel, senior author of the study who is also Professor of Biochemistry at the University of Buffalo said “Our earlier studies looked at newborn rats of the obese mothers in the post-weaning period, so we didn’t know how early this programming occurred," and added "Now we know it occurs in utero and specifically in the hypothalamus.” The professor opines that while the current studies were conducted on the rats, there is no reason to think that the system would be different in humans.
Metabolic programming is being studied from earlier times to observe the affect of a mother being malnourished during pregnancy on the offspring. The studies conclusively point out to long term affect of the malnutrition on babies starting from being underweight at birth to increased probability of attracting chronic diseases during adulthood.
This study points to one very important fact that the women should aim to maintain optimal conditions during their pregnancies. According to one of the studies conducted in 2003, one third of the pregnant ladies in US showed the tendency to become over weight and obese. This of course is something which is not good for the offspring in the long run.
"Our findings that malprogramming effects induced during fetal development in the altered intrauterine environment in obese mother rats predispose the offspring for adult-onset obesity underscore the importance of women maintaining optimal conditions during their pregnancies," Patel noted.
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September 1st, 2009 at 8:20 am
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September 1st, 2009 at 9:23 am
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September 1st, 2009 at 7:04 pm
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