New Way to Lose Fat
Feb 05, 2010
We all know that when we consume more than we burn, we gain weight. The key lies in the fact that we have to burn that extra fat to lose weight. Researchers have found a new method to trick the body into consuming more energy. This can be done with the help of an enzyme known "energy master switch." This is an enzyme known as Fyn kinase. This enzyme inhibits burning more fat.
Claire Bastie of the Albert Einstein College of Medicine and Neuroscience and her team showed that mice lacking Fyn kinase altogether burn more fatty acids and expend more energy to become leaner. They also showed other metabolic improvements, including increased insulin sensitivity. Those effects were the effect of higher levels of the master energy switch AMPK in their fat and muscle tissue.
Those findings can help in developing a new kind of weight loss drug. Now, the researchers are lobbying around the idea by showing that chemical inhibition of Fyn kinase with an experimental drug known only as SU6656 does have significant metabolic benefits for mice. Ultimately, the animals seem to be extremely fit because it lose fat and keep the lean. The researchers explained how the Fyn kinase works. It acts on another component of the energy pathway, which leads to a change in AMPK levels.
Bastie said that SU6656 itself isn’t a model drug candidate for clinical trials in humans. Because Fyn kinase and AMPK both have effect the brain as well as fat and muscle. Scientists should have to find out a new drug that doesn’t have these undesirable side effects. Bastie said, "Our next goal is to design something extremely specific to muscle and adipose."
She said she wants to figure out what are the functions of Fyn kinase and AMPK in the brain. She thinks they may play some role in appetite control. She also wants to find out what usually controls Fyn kinase levels.
Posted by admin | Tags: Weight Loss News
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