Promising Protection from Obesity Caused by Dietary Fats
Aug 31, 2009
A new chemical entity has been tested on mice at Ecole Polytechnique Fédérale de Lausanne in France that has shown tremendous potential to provide protection against diet-induced obesity. The enzyme known as SIRT1 very effectively enhances glucose tolerance and insulin sensitivity. It succeeded in accumulation of fat for strengthening specific body tissues and thus resulted in an increase in exercising stamina.
The study papers are presented in the latest issue of Cell Metabolism by the lead author Johan Auwerx, MD a professor at Ecole Polytechnique Fédérale de Lausanne.
Earlier studies have revealed that the occurrence of aging effects can be slowed down while developing endurance capabilities, if the caloric consumption is reduced by about 20%. It also helped in providing adequate protection against diet-induced obesity and related problems like diabetes etc. Some earlier studies also successfully demonstrated the ability of Resveratrol to give similar metabolic benefits if consumed in large doses. The researchers in the present study focused on the activation of enzyme SIRT1, which they believed, was responsible for managing the population and efficiency of mitochondria, the energy boosters in our cells.
The present research concentrated on finding the role of activated SIRT1 enzyme in controlling diet-induced obesity. SIRT1 also promoted utilization of fat in liver, skeletal muscles and brown adipose tissue and thus effectively curb the negative impacts of fat-rich diet on metabolism.
Johan Auwerx said "These results show that new synthetic SIRT1 activators can reproduce the positive metabolic effects that were previously demonstrated using resveratrol, a naturally occurring SIRT1 activator found in red wine. But unlike resveratrol, these new chemical entities target only the SIRT1 pathway, making them more selective and potent for achieving these metabolic benefits."
There is a huge interest in the people to check the occurrence of obesity and other metabolic disorders though the use of SIRT1 due to ineffectiveness of diet management plans and physical exercises.
Posted by admin | Tags: obesity
Add to: Digg | Del.icio.us | Stumble it!
You can leave a response, or trackback from your own site.
